Clustering the mast cell function-associated antigen (MAFA) induces tyrosyl phosphorylation of the FcεRI-β subunit
作者： Xu Rong , Israel Pecht
DOI: 10.1016/S0165-2478(96)02657-0
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摘要: Abstract The mast cell function associated antigen (MAFA) is a membranal glycoprotein identified on the surface membranes of rat mucosal-type cells RBL-2H3 line by monoclonal antibody (G63) binding to it. MAFA clustering mAb G63 causes dose-dependent inhibition these cells' response immunological stimulus provided type 1 Fce receptor (FceRI) suppressing biochemical processes coupling it mediator secretion. was found take place upstream production inositol phosphates and transient increase in free cytosolic Ca 2+ ion concentration, hence probably interferes with cascade at level protein tyrosyl kinases (PTK) activity. We have therefore examined whether affects phosphorylation components that time-dependent caused this modification FceRI-β chain. This constitutes first evidence for capacity clustered enhance, its own, changes cells, are most related inhibitory signaling capacity. Moreover, observed chain clearly indicates possible cross-talk between two membrane components.
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