Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases.
作者： Eiseman , Joseph B. Bolen
DOI: 10.1038/355078A0
关键词:
摘要: The high-affinity IgE receptor (Fc epsilon RI), which is expressed on the surface of mast cells and basophils, has a central role in immediate allergic responses. In rat basophilic leukaemia cell line RBL-2H3, model system for analysis Fc RI-mediated signal transduction, engagement RI induces histamine release tyrosine phosphorylation several distinct proteins. Although alpha, beta, gamma subunits lack intrinsic protein kinase (TPK) activity, that copurifies with phosphorylates beta residues. We report here RBL-2H3 cells, p56lyn pp60c-src are activated after crosslinking, coimmunoprecipitates RI. mouse mast-cell PT-18, another type used to study FC signalling, proteins also an consequence crosslinking. Notably, only detectable src protein-related TPK PT-18 p62c-yes, it this receptor. Therefore, seems different TPKs can associate same become engagement.
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sci-hub.se 参考文章(24)
L K Basciano, E H Berenstein, L Kmak, R P Siraganian, Monoclonal antibodies that inhibit IgE binding. Journal of Biological Chemistry. ,vol. 261, pp. 11823- 11831 ,(1986) , 10.1016/S0021-9258(18)67317-X
E. L. Ferry, C. A. Molinaro, J. W. Bohn, N. R. Klinman, L. A. Sherman, D. H. Katz, Fu-Tong Liu, H. Yamamoto, Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. Journal of Immunology. ,vol. 124, pp. 2728- 2737 ,(1980)
B.L. Hempstead, C.W. Parker, A. Kulczycki, The cell surface receptor for immunoglobulin E. Effect of tunicamycin on molecular properties of receptor from rat basophilic leukemia cells. Journal of Biological Chemistry. ,vol. 256, pp. 10717- 10723 ,(1981) , 10.1016/S0021-9258(19)68683-7
D Holowka, B Baird, Lactoperoxidase-catalyzed iodination of the receptor for immunoglobulin E at the cytoplasmic side of the plasma membrane. Journal of Biological Chemistry. ,vol. 259, pp. 3720- 3728 ,(1984) , 10.1016/S0021-9258(17)43154-1
Z Eshhar, I Alkalay, M Baniyash, Monoclonal antibodies specific to the alpha-subunit of the mast cell's Fc epsilon R block IgE binding and trigger histamine release. Journal of Immunology. ,vol. 138, pp. 2999- 3004 ,(1987)
L A Lipsich, A J Lewis, J S Brugge, Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses. Journal of Virology. ,vol. 48, pp. 352- 360 ,(1983) , 10.1128/JVI.48.2.352-360.1983
Joseph B. Bolen, Peter A. Thompson, Elisa Eiseman, Ivan D. Horak, Expression and Interactions of the Src Family of Tyrosine Protein Kinases in T Lymphocytes Advances in Cancer Research. ,vol. 57, pp. 103- 149 ,(1991) , 10.1016/S0065-230X(08)60997-5
André Veillette, Michael A. Bookman, Eva M. Horak, Joseph B. Bolen, The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck Cell. ,vol. 55, pp. 301- 308 ,(1988) , 10.1016/0092-8674(88)90053-0
A. Shimizu, I. Tepler, P. N. Benfey, E. H. Berenstein, R. P. Siraganian, P. Leder, Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 1907- 1911 ,(1988) , 10.1073/PNAS.85.6.1907
Rodolfo Quarto, Henry Metzger, The receptor for immunoglobulin E: examination for kinase activity and as a substrate for kinases. Molecular Immunology. ,vol. 23, pp. 1215- 1223 ,(1986) , 10.1016/0161-5890(86)90154-9