Fetuin in human bone marrow: detection in foetal tissue and patients with mastocytosis.

摘要: Fetuin, a foetal protein of unknown function, has been shown to be expressed in both the immune and nervous systems, especially during development. Here, we show for first time, that fetuin is abundantly present many cells human bone marrow, but restricted monocytic lineage adult. Fetuin's immunoreactivity increased considerably adult marrow some pathological conditions, particularly mastocytosis was also marrows cases acute leukaemias, myeloid leukaemia. This increase presence neoplastic not reflected by an level circulating fetuin. last observation contradicts earlier suggestions specifically reduced cancer patients. A consistent most mastocytosis, as demonstrated this paper, could become useful tool diagnosis disease.