Advances in understanding the anti-inflammatory properties of IL-27.

摘要: Initial studies on the biology of IL-27 provided evidence a role for this cytokine in initiation Th1 responses; however, subsequent work using models pathogen-induced and autoimmune inflammation have indicated that has broad inhibitory effects Th1, Th2 Th17 subsets T cells as well expansion inducible regulatory cells. While, aim review is to highlight functions context it will also serve elaborate molecular mechanisms involved production cytokine. The initial description classical antigen-presenting such macrophages dendritic produce IL-27, agonists signaling pathways activating transcription two subunits p28 EBV-induced gene 3 (EBI3) only recently been described.