Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis
作者： Atsushi Yamanaka , Shinjiro Hamano , Yoshiyuki Miyazaki , Kazunari Ishii , Atsunobu Takeda
DOI: 10.4049/JIMMUNOL.172.6.3590
关键词:
摘要: Administration of Con A induces liver injury that is considered to be an experimental model for human autoimmune or viral hepatitis, where immunopathology plays roles mediated by activated lymphocytes, especially NK1.1+ CD3+ NKT cells, and inflammatory cytokines, including IFN-gamma IL-4. In the present study we investigated role WSX-1, a component IL-27R, in A-induced hepatitis taking advantage WSX-1 knockout mice. WSX-1-deficient mice were more susceptible treatment than wild-type mice, showing serum alanine aminotransferase elevation massive necrosis liver. Although development cells appeared normal purified from produced IL-4 those response stimulation with both vitro vivo. addition, hyperproduction proinflammatory IL-1, IL-6, TNF-alpha, was observed after administration. These data revealed novel as inhibitory regulator cytokine production inflammation hepatitis.
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