Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

摘要: NK1.1+ CD4+ T cells produce more IL-4 and IFN-gamma in response to stimulation with anti-CD3 than conventional that have been primed be, respectively, Th2 or Th1 cells. Furthermore, even if cultured the absence of IL-4, whereas require develop into producers. The IFN-gamma-producing capacity is enhanced by IL-12. In addition, substantial amounts IL-3, IL-5, IL-10 upon stimulation. can be stimulated culture L expressing CD1 (L-CD1), but primary production was rather slow weak. Restimulation L-CD1-activated L-CD1 gave rise a much stronger rapid response, yielding comparable activation initially anti-CD3. L-CD1-primed resulted far less elicited from had anti-CD3, such substantially increased adding IL-12 culture. differing patterns cytokine suggest these may complex effects on priming not simply drive acquisition phenotype.