Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia.

作者: C. Iadecola , Colleen Forster , Shigeru Nogawa , H. Brent Clark , M. Elizabeth Ross

DOI: 10.1007/S004010051045

关键词:

摘要: … in the acute stages of cerebral ischemic infarction. Paraffin-… the middle cerebral artery territory were processed for COX-2 … suggest that COX-2 up-regulation is also relevant to cerebral …

参考文章(23)
Karen Seibert, Jaime Masferrer, Yan Zhang, Susan Gregory, Gary Olson, Scott Häuser, Kathleen Leahy, William Perkins, Peter Isakson, Mediation of inflammation by cyclooxygenase-2. Agents and actions. ,vol. 46, pp. 41- 50 ,(1995) , 10.1007/978-3-0348-7276-8_5
Kenneth K. Wu, Inducible Cyclooxygenase and Nitric Oxide Synthase Advances in pharmacology (San Diego). ,vol. 33, pp. 179- 207 ,(1995) , 10.1016/S1054-3589(08)60669-9
A. Tsai, L.C. Hsi, R.J. Kulmacz, G. Palmer, W.L. Smith, Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis. Journal of Biological Chemistry. ,vol. 269, pp. 5085- 5091 ,(1994) , 10.1016/S0021-9258(17)37658-5
Costantino Iadecola, Fangyi Zhang, Robyn Casey, Masao Nagayama, M. Elizabeth Ross, Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene The Journal of Neuroscience. ,vol. 17, pp. 9157- 9164 ,(1997) , 10.1523/JNEUROSCI.17-23-09157.1997
C. S. Williams, R. N. DuBois, Prostaglandin endoperoxide synthase: why two isoforms? American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 270, ,(1996) , 10.1152/AJPGI.1996.270.3.G393
David W. Busija, Clara Thore, Tracy Beasley, Ferenc Bari, Induction of Cyclooxygenase-2 Following Anoxic Stress in Piglet Cerebral Arteries Microcirculation. ,vol. 3, pp. 379- 386 ,(1996) , 10.3109/10739689609148310
S. Nogawa, C. Forster, F. Zhang, M. Nagayama, M. E. Ross, C. Iadecola, Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 10966- 10971 ,(1998) , 10.1073/PNAS.95.18.10966
W. E. Kaufmann, P. F. Worley, J. Pegg, M. Bremer, P. Isakson, COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 2317- 2321 ,(1996) , 10.1073/PNAS.93.6.2317
Masaki Nakayama, Koichi Uchimura, Raymond Li Zhu, Tetsuya Nagayama, Marie E Rose, R Anne Stetler, Peter C Isakson, Jun Chen, Steven H Graham, Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 10954- 10959 ,(1998) , 10.1073/PNAS.95.18.10954
J. L. Masferrer, B. S. Zweifel, P. T. Manning, S. D. Hauser, K. M. Leahy, W. G. Smith, P. C. Isakson, K. Seibert, Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 3228- 3232 ,(1994) , 10.1073/PNAS.91.8.3228