Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.

摘要: The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in brain. COX2 important mediator inflammation, but it not known whether pathogenic To study role ischemic injury brain, expression mRNA and protein effect treatment with a inhibitor on neuronal survival rat model global ischemia were determined. Expression both was increased after CA1 hippocampal neurons before their death. There rats treated COX2-selective SC58125 {1-[(4-methylsulfonyl) phenyl]-3-trifluoro-methyl-5-[(4-fluoro)phenyl] pyrazole} or compared vehicle controls. Furthermore, prostaglandin E2 concentrations 24 h decreased drug-treated animals vehicle-treated These results suggest that contributes to death ischemia.