Pathways involved in viral oncogenesis: New perspectives from virus-host protein interactomics.

摘要: Oncogenic viruses are among the apparent causes of cancer-associated mortality. It was estimated that 12% to 15% human malignancies linked oncoviruses. Although modernist strategies and traditional genetic studies have defined host-pathogen interactions oncoviruses, their host functions which critical for establishment infection still remain mysterious. However, over last few years, it has become clear infections hijack modify cellular pathways benefit. In this context, we constructed virus-host protein interaction networks seven oncoviruses (EBV, HBV, HCV, HTLV-1, HHV8, HPV16, HPV18), revealed hijacking as a result oncogenic virus infection. Several signaling pathways/processes such TGF-β signaling, cell cycle, retinoblastoma tumor suppressor protein, androgen receptor were mutually targeted by induce oncogenesis. Besides, specific certain detected. By study, believe improve understanding molecular pathogenesis viral oncogenesis provide information in setting new targets treatment, prognosis, diagnosis.