The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both?

摘要: Background Anemia and red blood cell (RBC) transfusions are both associated with morbidity mortality after cardiac surgery. Patients the lowest hematocrit (HCT) values during cardiopulmonary bypass (CPB) most likely to receive a transfusion, which results in double-negative exposure. We aimed clarify effects of anemia, their combination identify imposes greatest risk end-organ dysfunction mortality. Methods From November 1, 2004, 2009, 7942 patients underwent procedures requiring CPB did not intraoperative or postoperative RBC 1202 received transfusion alone. They were divided into 4 groups: nadir HCT ≥25% without Results After adjustment, comparison all groups showed that double exposure anemia (HCT P  = .008), highest troponin (  = .01), longest ventilator requirement  = .007). Single either Conclusions Although single alone was risk, it generally lower than combination.