摘要: A unique subset of interneurons which are rich in immunoreactive somatostatin (IRS) exists the cerebral cortex. The regulation IRS secretion by these cells is reviewed. Acetylcholine, glutamic acid and several neuropeptides including VIP, CCK, metenkephalin have been identified as secretagogues. types molecules stimulate release, electrophysiologic effects somatostatin, recognition abnormal levels human CNS diseases were all used to formulate a working model role somatostatinergic cell ongoing cortical function.
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