Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats

摘要: Fibrates are hypolipidemic drugs that activate the peroxisome proliferator-activated receptors. Since fibrates may also increase energy expenditure, we investigated whether fenofibrate (FF) had this effect in diet-induced obese rats. A 2-month administration of a high-fat palatable diet to adult rats increased body weight by 25% and white adipose mass 163% compared with standard diet. These effects were prevented FF, both when administered for 2 months feeding given only second month. Consequently, FF-treated final tissue similar untreated animals on FF resting metabolic rate, hepatic peroxisomal mitochondrial palmitoyl-dependent oxygen uptake mRNA levels acyl-CoA oxidase lipoprotein lipase. Finally, lowered uncoupling protein-2 did not affect respiration skeletal muscle. Therefore, seems act as weight-stabilizer mainly through its liver metabolism.