Recovery of the Hypothalamic-Pituitary-Adrenal Axis in Children and Adolescents after Surgical Cure of Cushing's Disease
作者： Maya Lodish , Somya Verma Dunn , Ninet Sinaii , Margaret F. Keil , Constantine A. Stratakis
DOI: 10.1210/JC.2011-2325
关键词:
摘要: Context: Recovery of the hypothalamic-pituitary-adrenal axis (HPAA) after transsphenoidal surgery (TSS) for Cushing's disease (CD) in children has not been adequately studied. Objective: Our objective was to assess time recovery HPAA TSS with CD. Design and Setting: This a case series at National Institutes Health Clinical Center. Patients: Fifty-seven patients CD (6–18 yr, mean 13.0 ± 3.1 yr) given standard regimen glucocorticoid tapering were studied out total 73 recruited. Interventions: ACTH (250 μg) stimulation tests administered approximately 6-month intervals up 36 months. Age, sex, pubertal status, body mass index, length disease, midnight cortisol, urinary free cortisol diagnosis analyzed effects on recovery. Main Outcome Measure: The main outcome measure complete as defined by level least 18 μg/dl response 250 μg ACTH. Results: Full rea...
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