Ostéonécrose des maxillaires et bisphosphonates.

摘要: Widely prescribed, bisphosphonates inhibit bone resorption. They are not metabolised and have long half-lives. Two cases of osteonecrosis the jaws recently been attributed to at University Hospital Geneva. The recent literature reveals more than a hundred similar throughout world. Bone exposure appears spontaneously or after dental care. Treatment is controversial cure very difficult. This pathology usually seen in patients on chemotherapy, steroids i.v. bisphosphonates, but sometimes with low-dose p.o. bisphosphonates. In view strong association between bisphosphonate therapy jaw, specialists recommended oral evaluation during as well for several years drug discontinuation.