Clinical evaluation of oral chronic graft-versus-host disease.

摘要: Abstract Oral chronic graft-versus-host disease (cGVHD) is a significant and serious complication following allogeneic hematopoietic stem cell transplantation (HSCT). The purpose of this study was to characterize the distribution, type, extent lesions their correlation with patient-reported symptoms such as pain discomfort. effect time since on these measures also assessed. Consecutive patients oral cGVHD referred Center for Disease at Brigham Women's Hospital, Boston, MA, were evaluated over 2-year period. Subjective data included responses 4 targeted symptom questions (yes/no) visual analog scale score (0-10). Objective location reticulation, erythema, ulcerations using previously published scoring system well HSCT. Multiple linear regression analyses performed SAS. We 27 patients, total 79 clinic visits (median 2, range: 1-8). median HSCT 18 months (range: 5-157 months). buccal labial mucosa tongue sites 93% all ulcerations, 72% erythematous lesions, 76% reticular most frequently affected sites. gingiva, floor mouth, hard soft palate infrequently affected. Although uncommon, ulceration objective finding highly correlated increased (P