Modified Glasgow Prognostic Score is predictive of prognosis for non-small cell lung cancer patients treated with stereotactic body radiation therapy: a retrospective study.

作者: Eiji Nakatani , Ryo Saito , Mitsuhiko Oguri , Kengo Kuriyama , Kan Marino

DOI: 10.1093/JRR/RRAB021

关键词:

摘要: We aimed to assess the predictive value of modified Glasgow prognostic score (mGPS) in patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body radiation therapy (SBRT). retrospectively reviewed records 207 patients, a median age 79 years. The pretreatment mGPS was calculated and categorized as high (mGPS = 1-2) or low 0). follow-up duration 40.7 months. five-year overall survival (OS), progression-free (PFS) time progression (TTP) rates were 44.3%, 36% 54.4%, respectively. Multivariate analysis revealed that independently OS (hazard ratio [HR] 1.67; 95% confidence interval 1.14-2.44: P 0.009), PFS (HR 1.58; 1.10-2.28: 0.014) TTP 1.66; 1.03-2.68: 0.039). Patients had showed significantly worse (33.3 vs 64.5 months, 0.003) (23.8 39 0.008) than those mGPS. data trend suffered earlier compared (54.3 88.1 0.149). confirmed is prognosis NSCLC treated SBRT.

参考文章(43)
Tolia G Maria, Kouloulias E Vasileios, Pantelakos S Panagiotis, Syrigos N Kostas, None, Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy. International Journal of Clinical and Experimental Medicine. ,vol. 6, pp. 50- 56 ,(2013)
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Takahiro Kishi, Yukinori Matsuo, Nami Ueki, Yusuke Iizuka, Akira Nakamura, Katsuyuki Sakanaka, Takashi Mizowaki, Masahiro Hiraoka, Pretreatment Modified Glasgow Prognostic Score Predicts Clinical Outcomes After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer. International Journal of Radiation Oncology Biology Physics. ,vol. 92, pp. 619- 626 ,(2015) , 10.1016/J.IJROBP.2015.02.018
Mitsuaki Kawashima, Tomohiro Murakawa, Tomohiro Shinozaki, Junji Ichinose, Haruaki Hino, Chihiro Konoeda, Takehiro Tsuchiya, Tomonori Murayama, Kazuhiro Nagayama, Jun-ichi Nitadori, Masaki Anraku, Jun Nakajima, Significance of the Glasgow Prognostic Score as a prognostic indicator for lung cancer surgery Interactive Cardiovascular and Thoracic Surgery. ,vol. 21, pp. 637- 643 ,(2015) , 10.1093/ICVTS/IVV223
L M Forrest, D C McMillan, C S McArdle, W J Angerson, D J Dunlop, Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. British Journal of Cancer. ,vol. 89, pp. 1028- 1030 ,(2003) , 10.1038/SJ.BJC.6601242
Donald C. McMillan, Maqsood M. Elahi, Naveed Sattar, Wilson J. Angerson, Jennie Johnstone, Colin S. McArdle, Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer. Nutrition and Cancer. ,vol. 41, pp. 64- 69 ,(2001) , 10.1080/01635581.2001.9680613
Hiroshi Onishi, Kengo Kuriyama, Takafumi Komiyama, Shiho Tanaka, Naoki Sano, Kan Marino, Satoshi Ikenaga, Tsutomu Araki, Minoru Uematsu, Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner Lung Cancer. ,vol. 45, pp. 45- 55 ,(2004) , 10.1016/J.LUNGCAN.2004.01.004
D J McKeown, D J F Brown, A Kelly, A M Wallace, D C McMillan, The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer British Journal of Cancer. ,vol. 91, pp. 1993- 1995 ,(2004) , 10.1038/SJ.BJC.6602248
Donald C. McMillan, Joseph E. M. Crozier, Khalid Canna, Wilson J. Angerson, Colin S. McArdle, Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. International Journal of Colorectal Disease. ,vol. 22, pp. 881- 886 ,(2007) , 10.1007/S00384-006-0259-6
Michael J. Proctor, David S. Morrison, Dinesh Talwar, Steven M. Balmer, Colin D. Fletcher, Denis St.J. O’Reilly, Alan K. Foulis, Paul G. Horgan, Donald C. McMillan, A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study European Journal of Cancer. ,vol. 47, pp. 2633- 2641 ,(2011) , 10.1016/J.EJCA.2011.03.028