Transport and distribution of α-tocopherol in lymph, serum and liver cells in rats
作者： Anders Bjørneboe , Gunn-Elin Aa. Bjørneboe , Egil Bodd , Bente F. Hagen , Nils Kveseth
DOI: 10.1016/0167-4889(86)90193-X
关键词:
摘要: Rats were cannulated in the major mesenteric lymph duct and given an intraduodenal bolus of unlabeled α-[3H]tocopherol, [14C]oleic acid soybean oil. The appearance α-tocopherol was negligible during first 2 h peaked 4–15 after feeding, whereas no detectable amount recovered portal vein. Intestinal absorption via lymphatic pathway 15.4 ± 8.9% (n = 10) 45.9 10.8% 4) for acid, respectively. About 99% associated with chylomicron fraction (d < 1.006 g/ml). In non-fasting rats, 51% serum chylomicrons/VLDL (very-low-density lipoprotein, d g/ml) 47% HDL (high-density 1.05 1.21 Our study revealed that liver, skeletal muscle adipose tissue contain approx. 92% total mass measured ten different organs. Parenchymal nonparenchymal liver cells contributed to 75% 25%
elsevier.com
sci-hub.se 参考文章(31)
D Hollander, INTESTINAL ABSORPTION OF VITAMINS A, E, D, AND K Journal of Laboratory and Clinical Medicine. ,vol. 97, pp. 449- 462 ,(1981)
Ruth Porter, Julie Whelan, Biology of vitamin E Pitman , Distributed in North America by CIBA Pharmaceutical Co. (Medical Education Division). ,(1983)
S. Dueland, J.I. Pedersen, P. Helgerud, C.A. Drevon, Transport of vitamin D3 from rat intestine. Evidence for transfer of vitamin D3 from chylomicrons to alpha-globulins. Journal of Biological Chemistry. ,vol. 257, pp. 146- 150 ,(1982) , 10.1016/S0021-9258(19)68338-9
J.T. Gwynne, B. Hess, The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis. Journal of Biological Chemistry. ,vol. 255, pp. 10875- 10883 ,(1980) , 10.1016/S0021-9258(19)70388-3
R Blomhoff, M Rasmussen, A Nilsson, K R Norum, T Berg, W S Blaner, M Kato, J R Mertz, D S Goodman, U Eriksson, Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. Journal of Biological Chemistry. ,vol. 260, pp. 13560- 13565 ,(1985) , 10.1016/S0021-9258(17)38759-8
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
M G Traber, H J Kayden, Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein The American Journal of Clinical Nutrition. ,vol. 40, pp. 747- 751 ,(1984) , 10.1093/AJCN/40.4.747
B Halliwell, J M C Gutteridge, OXYGEN TOXICITY, OXYGEN RADICALS, TRANSITION METALS AND DISEASE Biochemical Journal. ,vol. 219, pp. 1- 14 ,(1984) , 10.1042/BJ2190001
Daniel Hollander, Elena Rim, K.S. Muralidhara, Mechanism and Site of Small Intestinal Absorption of α-Tocopherol in the Rat Gastroenterology. ,vol. 68, pp. 1492- 1499 ,(1975) , 10.1016/S0016-5085(75)80137-5
K Grankvist, S L Marklund, I B Täljedal, CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse Biochemical Journal. ,vol. 199, pp. 393- 398 ,(1981) , 10.1042/BJ1990393