Riboswitches as antibacterial drug targets.
作者： Kenneth F Blount , Ronald R Breaker
DOI: 10.1038/NBT1268
关键词:
摘要: … small drug-like metabolites. In most cases, metabolite binding to the receptor represses the expression of the gene(s) encoded by the mRNA. If a new metabolite analog were designed …
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Peter A. McNamara, Trends in RNA research Nova Science Publishers. ,(2006)
Akio IWASHIMA, Yasuo WAKABAYASHI, Yoshitsugu NOSE, Formation of pyrithiamine pyrophosphate in brain tissue. Journal of Biochemistry. ,vol. 79, pp. 845- 847 ,(1976) , 10.1093/OXFORDJOURNALS.JBCHEM.A131138
Sukeerthi Seetharaman, Maris Zivarts, Narasimhan Sudarsan, Ronald R. Breaker, Immobilized RNA switches for the analysis of complex chemical and biological mixtures. Nature Biotechnology. ,vol. 19, pp. 336- 341 ,(2001) , 10.1038/86723
H H Saxild, P Nygaard, Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs. Journal of Bacteriology. ,vol. 169, pp. 2977- 2983 ,(1987) , 10.1128/JB.169.7.2977-2983.1987
Thomas Hermann, Yitzhak Tor, RNA as a target for small-molecule therapeutics Expert Opinion on Therapeutic Patents. ,vol. 15, pp. 49- 62 ,(2005) , 10.1517/13543776.15.1.49
Maumita Mandal, Ronald R. Breaker, Gene regulation by riboswitches. Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 451- 463 ,(2004) , 10.1038/NRM1403
Alexander Serganov, Anna Polonskaia, Anh Tuân Phan, Ronald R. Breaker, Dinshaw J. Patel, Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature. ,vol. 441, pp. 1167- 1171 ,(2006) , 10.1038/NATURE04740
Yang Lu, Tamara N. Shevtchenko, Henry Paulus, Fine-structure mapping of cis-acting control sites in the lysC operon of Bacillus subtilis. Fems Microbiology Letters. ,vol. 92, pp. 23- 27 ,(1992) , 10.1111/J.1574-6968.1992.TB05230.X
Ali Nahvi, Jeffrey E Barrick, Ronald R Breaker, Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes Nucleic Acids Research. ,vol. 32, pp. 143- 150 ,(2004) , 10.1093/NAR/GKH167
Richard L. Monaghan, John F. Barrett, Antibacterial drug discovery—Then, now and the genomics future Biochemical Pharmacology. ,vol. 71, pp. 901- 909 ,(2006) , 10.1016/J.BCP.2005.11.023