Antifungal agents used in systemic mycoses. Activity and therapeutic use.

摘要: The development of the polyene antibiotic, amphotericin B, provided for first time a drug which was clinically effective in many serious mycotic diseases. Unfortunately, it requires parenteral administration and is often toxic, factors limit total cumulative dose can be given. Efforts to utilise combinations B with other agents were best realised B/flucytosine cryptococcal meningitis, lesser degree systemic candidiasis. More recently, introduction new imidazoles has extended range applications these drugs fungal Two members this group, miconazole ketoconazole, are promising agents. Miconazole parenterally administered agent patients acutely ill candidiasis infections. It may choice Petriellidium boydii infections an attractive alternative intrathecal meningitis. Ketoconazole offers much less toxicity, advantage oral administration, possibility indefinitely prolonged therapy. However, does not attain high concentrations either urine or cerebrospinal fluid. With imidazoles, we have entered era antifungal therapy produce even better than those currently available.