Mechanism of Action of an Anti-Candida Drug: Amphotericin B and Its Derivatives
作者： J. Bolard
DOI: 10.1007/978-3-642-75253-7_14
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摘要: The selection of anti-Candida drugs is based on their selective toxicity towards the fungal pathogen. in turn depends cellular constituents and biosynthetic pathways Fungi, like host cells, are also eukaryotic organisms hence both similar most respects. presence ergosterol membranes instead cholesterol has been basis development two principal categories antifungal drugs: polyene antibiotics azole derivatives. Many chemotherapists have so far unsuccessfully directed efforts targeting new to Candida’s cell wall. approach any case offers great promise. recent important developments field derivatives, delivery by liposomes, aimed against With regard other mechanism action, no significant progress made. Several books entirely devoted chemotherapy [39,146,158]. There excellent articles published all [44,104,75,160] or more specifically, [12,41,77,103,132] derivatives [159]. phenotypic resistance Candida albicans reviewed [42,134]. This chapter mainly updating our knowledge proposal interpretations action polyene, amphotericin B (AmB) its
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