Minimal invasive surgical procedure of inducing myocardial infarction in mice.

摘要: Myocardial infarction still remains the main cause of death in western countries, despite considerable progress stent development area last decades. For clarification underlying mechanisms and new therapeutic strategies, availability valid animal models are mandatory. Since we need insights into pathomechanisms cardiovascular diseases under vivo conditions to combat myocardial infarction, validity model is a crucial aspect. However, protection animals highly relevant this context. Therefore, establish minimally invasive simple mice, which assures high reproducibility survival rate animals. Thus, fulfils requirements 3R principle (Replacement, Refinement Reduction) for experiments assure scientific information needed further developing therapeutical strategies diseases.