Implantation of bone marrow mononuclear cells using injectable fibrin matrix enhances neovascularization in infarcted myocardium.
作者： Ju Hee Ryu , Il-Kwon Kim , Seung-Woo Cho , Myeong-Chan Cho , Kyung-Kuk Hwang
DOI: 10.1016/J.BIOMATERIALS.2004.02.058
关键词: Cardiology 、 Materials science 、 Bone marrow 、 Neovascularization 、 Myocardial infarction 、 Fluorescence microscope 、 Matrix (biology) 、 Cardiac function curve 、 Internal medicine 、 Infarction 、 Peripheral blood mononuclear cell
摘要: Abstract Neovascularization may improve cardiac function and prevent further scar tissue formation in infarcted myocardium. A number of studies have demonstrated that bone marrow-derived cells the potential to induce neovascularization ischemic tissues. In this study, we hypothesized implantation marrow mononuclear (BMMNCs) using injectable fibrin matrix enhances myocardium compared BMMNC without matrix. To test hypothesis, infarction was induced rat by cryoinjury. Three weeks later, BMMNCs were mixed with injected into Injection either or medium alone served as controls. Eight after treatments, histological analyses indicated resulted more extensive regeneration Examination fluorescence microscopy revealed labeled a fluorescent dye prior survived at 8 implantation. Importantly, much than The microvessel density significantly higher (p
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