Possible Association of the Human KCNE1 (minK) Gene and QT Interval in Healthy Subjects: Evidence from Association and Linkage Analyses in Israeli Families

摘要: Summary QT interval prolongation is associated with increased risk of sudden and non-sudden cardiac death. Potassium channel gene variants are inherited long QT syndromes. Using linkage association analyses, we investigated whether in the potassium subunit KCNE1 QTc intervals an unselected population sample 80 kindreds living kibbutz settlements Israel. Variance-component analysis revealed weak evidence polymorphisms intervals. Family-based showed a significant between G38S polymorphism interval. Further quantitative trait demonstrated residual heritability component (h2= 0.33), that effect variant allele modified by gender. Estimated maximum likelihood parameters from these models indicated male gender, age, hypertension, diabetes, hypercholesterolemia, fibrinogen BMI were positively interval; level education cigarette smoking inverse association. Both erythrocyte membrane n-6 n-3 fatty acids While more than 15.8% variability was contributed covariates, another 4.7% explained dietary factors, 2.2%, approximately 36% polygenes. An silico also novel V80 SNP, synonymous variant, abolishes recognition for splicing enhancer, which may lead to mutation. These results demonstrate that, addition polygenic background, factors other covariables, involved determining levels this population-based families.