Treatment of tardive dyskinesia with vitamin E.

摘要: Objective Vitamin E (alpha-tocopherol), a free-radical scavenger, has been reported to improve symptoms of tardive dyskinesia. The authors attempted replicate this finding under more controlled conditions in larger study group. Method Fifteen inpatients and six outpatients with dyskinesia received up 1600 IU/day vitamin for 6 weeks double-blind, placebo-controlled crossover study. Abnormal Involuntary Movement Scale (AIMS) examinations these patients were videotaped rated independently by two trained raters. Levels neuroleptic medication measured during both treatment periods. Eighteen who demonstrated high blood levels included the data analysis. Results significantly higher while receiving than they placebo. For all 18 patients, there no significant differences between AIMS scores after In agreement previous studies, however, nine had 5 years or less lower There changes treatment. Conclusions minor beneficial effect on ratings selected group less. This was not due an increase medications.