Reactivity pattern of 15 HLA-Dw1 homozygous typing cells in primary mixed lymphocyte culture.

摘要: The Dwl specificity was highly correlated with the serologically determined HLA-DR1 antigen in Eighth International Histocompatibility Workshop 1980. By testing a large number of HLA-Dwl, DR1 defined homozygous typing cells (HTC) checkerboard primary mixed lymphocyte reaction, on panel about 30 heterozygous individuals, and family segregation, three “subtypes” could be association certain HLA-A, -B, -C-antigens. HTC TA, FRI, FRA carrying HLA haplotypes A11, B35, Cw4 or A3, state gave positive results most members stimulated only four other Dw1 HTCs (SRR≦35%). In contrast to this operationally “broad” specificity, Dw1-HTC-HEN (HLA-A2, B44, C-, homozygous) non-stimulatory all except one, but high responses against these, leading definition “narrow” included one. Another such represented by FEE B27, Cw2 homozygous). Typing patterns were mostly different from those HTC. studies specific pattern for shown segregate HLA. However, within some these contribution haplotype trans position must assumed.