Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells
作者： Cuiping Zhao , Qingjie Wang , Sally Temple
DOI: 10.1242/DEV.133108
关键词:
摘要: Retinal degenerative diseases are the leading causes of blindness worldwide. Replacing lost retinal cells via stem cell-based therapies is an exciting, rapidly advancing area translational research that has already entered clinic. Here, we review status these clinical efforts for several significant diseases, describe challenges involved and discuss how basic developmental studies have contributed to needed advance goals.
biologists.com
biologists.org参考文章(135)
Emily Y Chew, Traci E Clemons, Elvira Agrón, Robert D Sperduto, John Paul SanGiovanni, Natalie Kurinij, Matthew D Davis, Age-Related Eye Disease Study Research Group, None, Long-Term Effects of Vitamins C and E, β-Carotene, and Zinc on Age-related Macular Degeneration: AREDS Report No. 35 Ophthalmology. ,vol. 120, pp. 1604- 1611 ,(2013) , 10.1016/J.OPHTHA.2013.01.021
E L Berson, Retinitis pigmentosa. The Friedenwald Lecture. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 1659- 1676 ,(1993)
Robert E MacLaren, Mandeep S Singh, Alona O Cramer, Alun R Barnard, Sher A Aslam, Isabel L Duncan, Cell fusion following photoreceptor transplantation into the non-degenerate retina Investigative Ophthalmology & Visual Science. ,vol. 55, pp. 3989- 3989 ,(2014)
Paulo E Stanga, Andres Kychenthal, Frederick W Fitzke, Anthony S Halfyard, Roger Chan, Alan C Bird, George W Aylward, Retinal pigment epithelium translocation after choroidal neovascular membrane removal in age-related macular degeneration 3 3The authors have no proprietary or financial interest related to this manuscript. Ophthalmology. ,vol. 109, pp. 1492- 1498 ,(2002) , 10.1016/S0161-6420(02)01099-0
Sabine Fuhrmann, Eye Morphogenesis and Patterning of the Optic Vesicle Current Topics in Developmental Biology. ,vol. 93, pp. 61- 84 ,(2010) , 10.1016/B978-0-12-385044-7.00003-5
P M Conneally, J A Boughman, W E Nance, Population genetic studies of retinitis pigmentosa. American Journal of Human Genetics. ,vol. 32, pp. 223- 235 ,(1980)
Dean Bok, Xiaoyan Zhang, Transplantation of retinal pigment epithelial cells and immune response in the subretinal space Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 1021- 1027 ,(1998)
Valentin M. Sluch, Donald J. Zack, Stem Cells, Retinal Ganglion Cells, and Glaucoma Developments in ophthalmology. ,vol. 53, pp. 111- 121 ,(2014) , 10.1159/000358409
Teisha J. Rowland, Alison J. Blaschke, David E. Buchholz, Sherry T. Hikita, Lincoln V. Johnson, Dennis O. Clegg, Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins Journal of Tissue Engineering and Regenerative Medicine. ,vol. 7, pp. 642- 653 ,(2013) , 10.1002/TERM.1458
Andrei Glinka, Wei Wu, Darya Onichtchouk, Claudia Blumenstock, Christof Niehrs, Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus Nature. ,vol. 389, pp. 517- 519 ,(1997) , 10.1038/39092