Effects of Ancrod (Arvin) in Mice: Studies of Plasma Fibrinogen and Fibrinolytic Activity

摘要: Summary. Plasma fibrinogen and its degradation products (FDP) were examined in mice given single injections of Ancrod, the purified coagulative fraction Malayan pit viper venom previously called Arvin. Clottable had disappeared completely 5 min after injection slowly reappeared 12 hr later. At least 2 FDP appeared plasma 30 while later only one was present which corresponded to human fragment E. This contrast vitro lysis mouse yielded two late corresponding fragments D E. The fibrinolytic system also these animals. injection, plasminogen decreased amount but increased susceptibility activation by urokinase. Transient, modest increases activity evident diluted samples 1 again 8 injections. Inhibitors fibrinolysis did not differ from those normal mice. These observations are correlated with our previous immunofluorescent histochemical studies on other The data support earlier conclusion that within small vessels tissues is major importance reaction Ancrod.