QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice.

摘要: Patients with familial hypertrophic cardiomyopathy (FHC) are at risk for ventricular arrhythmias and sudden death. Regional variability in the QT interval [QT dispersion (QTd)] is significantly increased humans FHC arrhythmias. A mouse model of resulting from a mutation α-myosin heavy-chain (Arg403Gln) was used to study electrophysiologic phenotype this disease. Cardiac electrophysiology studies surface ECGs were performed mice wild-type controls evaluate feasibility significance QTd measurements predicting Atrial pacing electrodes placed by either transvenous or epicardial approach. Standard extrastimulus protocols followed. The measured six ECG leads. defined as difference between maximum minimum intervals. Male had greater than (37.1 ± 3.0 ms versus 23.9 1.9 ms, p = 0.001). There also significant gender within each genotype; female male (37.4 5.3 0.005), 27.2 2.0 0.02). Twelve 23 inducible arrhythmias, whereas only 2 32 (p 0.004). Although number compared mice, did not correlate arrhythmia inducibility. importance that it validates further investigation arrhythmogenic differences FHC. It suggests although gender- genotype-specific values increased, they do predict mice.