T‐peak to T‐end interval may be a better predictor of high‐risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin i mutation than qt dispersion
作者： Masami Shimizu , Hidekazu Ino , Kazuyasu Okeie , Masato Yamaguchi , Mitsuru Nagata
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摘要: Background: Patients with hypertrophic cardiomyopathy (HCM) associated a deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene suffer sudden death at all ages. However, correlation between QT variables and these patients remains uncertain. Hypothesis: We evaluated and/or ventricular tach-yarrhythmia (SCD/VT) HCM cTnI mutation. Methods: analyzed 10 probands K183del their family members. The subjects were divided into three groups: Group A (n = 7), mutation carriers SCD/VT; B 16), without C 24), no carriers. intervals corrected using Bazett's formula. Results: Maximum QTc dispersion significantly longer Groups than C. there differences either parameter B. On contrary, peak-to-end interval T wave/QT V5 (Tpe) was that Logistic regression analysis revealed Tpe good clinical predictor for SCD/VT this study. Conclusions: These results suggest rather may be one best predictors gene.
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