Serum Uric Acid Levels and Risk of Metabolic Syndrome in Healthy Adults
作者： Pantea Ebrahimpour , Hossein Fakhrzadeh , Ramin Heshmat , Fatemeh Bandarian , Bagher Larijani
DOI: 10.4158/EP.14.3.298
关键词:
摘要: Objective: To investigate the relationship between hyperuricemia and metabolic syndrome in a population of healthy subjects. Methods: We studied 1,573 adults (25 to 64 years old) laboratory Tehran University Medical Sciences. The study was designed according World Health Organization MONICA (Multinational Monitoring Trends Determinants Cardiovascular Disease) project with use National Cholesterol Education Program Adult Treatment Panel III criteria for syndrome. Results: crude prevalence 29.9% (age-adjusted, 27.5%). rate significantly increased higher quartiles serum uric acid both sexes but especially women (P<.0001 versus P = .026). bivariate correlation significant levels age, total cholesterol, high-density lipoprotein triglycerides, body mass index, waist hip circumferences, waist-to-hip ratio, systolic diastolic blood pressures; however, there not concentrations fasting plasma glucose. Conclusion: These data indicate that an independent exists Moreover, is correlated hypertriglyceridemia, hypertension, visceral obesity. Early detection seems be essential prevention
metapress.com参考文章(35)
David Conen, V Wietlisbach, P Bovet, C Shamlaye, W Riesen, F Paccaud, M Burnier, Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country BMC Public Health. ,vol. 4, pp. 9- 9 ,(2004) , 10.1186/1471-2458-4-9
Roubenoff R, Gout and hyperuricemia. Rheumatic Diseases Clinics of North America. ,vol. 16, pp. 539- 550 ,(1990)
Reaven Gm, Syndrome X: 6 years later Journal of internal medicine. Supplement. ,vol. 736, pp. 13- 22 ,(1994)
S. Bo, P. Cavallo-Perin, L. Gentile, E. Repetti, G. Pagano, Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes European Journal of Clinical Investigation. ,vol. 31, pp. 318- 321 ,(2001) , 10.1046/J.1365-2362.2001.00812.X
Michael Schachter, Uric acid and hypertension. Current Pharmaceutical Design. ,vol. 11, pp. 4139- 4143 ,(2005) , 10.2174/138161205774913246
Tae Woo Yoo, Ki Chul Sung, Hun Sub Shin, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Man Ho Lee, Jung Ro Park, Hyang Kim, Eun Jung Rhee, Won Young Lee, Sun Woo Kim, Seung Ho Ryu, Dong Geuk Keum, Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome Circulation. ,vol. 69, pp. 928- 933 ,(2005) , 10.1253/CIRCJ.69.928
A. Costa, I. Igual[aacute], J. Bedini, L. Quint[oacute], I. Conget, Uric acid concentration in subjects at risk of type 2 diabetes mellitus: Relationship to components of the metabolic syndrome Metabolism-clinical and Experimental. ,vol. 51, pp. 372- 375 ,(2002) , 10.1053/META.2002.30523
Ryuichi Kawamoto, Hitomi Tomita, Yuichiro Oka, Nobuyuki Ohtsuka, Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclerosis. Internal Medicine. ,vol. 45, pp. 605- 614 ,(2006) , 10.2169/INTERNALMEDICINE.45.1661
Gregory S Cohn, Michelle M Kittleson, Roger S Blumenthal, None, Toward an improved diagnosis of the metabolic syndrome other clues to the presence of insulin resistance. American Journal of Hypertension. ,vol. 18, pp. 1099- 1103 ,(2005) , 10.1016/J.AMJHYPER.2005.02.004
Norman M. Kaplan, The Deadly Quartet and the Insulin Resistance Syndrome: An Historical Overview Hypertension Research. ,vol. 19, pp. S9- S11 ,(1996) , 10.1291/HYPRES.19.SUPPLEMENTI_S9