Neuronal Aneuploidy in Health and Disease: A Cytomic Approach to Understand the Molecular Individuality of Neurons
作者： Thomas Arendt , Birgit Mosch , Markus Morawski
DOI: 10.3390/IJMS10041609
关键词:
摘要: Structural variation in the human genome is likely to be an important mechanism for neuronal diversity and brain disease. A combination of multiple different forms aneuploid cells due loss or gain whole chromosomes giving rise cellular at genomic level have been described neurons normal diseased adult brain. Here, we describe recent advances molecular neuropathology based on slide-based cytometry with biological techniques that will contribute understanding genetic heterogeneity CNS its potential impact Alzheimer's disease age-related disorders.
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