Inhibitory Effect of Piceatannol on TNF-α-Mediated Inflammation and Insulin Resistance in 3T3-L1 Adipocytes.
作者： Yanfang Li , Puyu Yang , Qimeng Chang , Jing Wang , Jie Liu
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摘要: Piceatannol, a bioactive component in grape and blueberry, was examined for its potential decreasing the inflammatory activities adipocytes using cocultured adipocyte macrophage system, suppressing tumor necrosis factor-α (TNF-α)-mediated inflammation related insulin resistance 3T3-L1 model. Piceatannol at 10 μM significantly reduced release of cytokines TNF-α monocyte chemoattractant protein-1 (MCP-1) by 19 31% respectively. Pretreatment with piceatannol also inhibited TNF-α-induced expression interleukin-6 (IL-6) MCP-1 both mRNA protein levels adipocytes. partially improved malfunction insulin-stimulated glucose uptake, which Furthermore, inhibitions were mediated significant blocking IκBα phosphorylation nuclear factor-κB (NF-κB) activation through translocation NF-κB p65 along ...
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