Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
作者： Ivana Bjedov , Janne M. Toivonen , Fiona Kerr , Cathy Slack , Jake Jacobson
DOI: 10.1016/J.CMET.2009.11.010
关键词:
摘要: The target of rapamycin (TOR) pathway is a major nutrient-sensing that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. central component this pathway, TOR kinase, the inhibitory drug rapamycin, highly specific and well-described approved for human use. We show here that feeding to adult Drosophila produces extension seen some mutants. Increase by was associated with increased resistance both starvation and paraquat. Analysis underlying mechanisms revealed longevity specifically through TORC1 branch alterations autophagy translation. Rapamycin could increase weak insulin/Igf signaling (IIS) mutants flies maximized dietary restriction, indicating additional mechanisms.
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