Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.
作者： Nancy Luong , Claire R. Davies , Robert J. Wessells , Suzanne M. Graham , M. Todd King
DOI: 10.1016/J.CMET.2006.05.013
关键词:
摘要: Summary Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable conditions by regulating the diapause state, whereby organism stockpiles lipids, reduces fertility, increases stress resistance, and has an increased lifespan. The Target Rapamycin (TOR) responds to changes in growth factors, amino acids, oxygen tension, energy status; however, it is unclear how TOR contributes physiological homeostasis disease conditions. Here, we show that reducing function Drosophila results decreased lipid stores glucose levels. Importantly, this reduction dTOR activity blocks insulin resistance metabolic syndrome phenotypes associated with responsive transcription factor, dFOXO. Reduction also protects against age-dependent decline heart longevity. Thus, regulation may be ancient "systems biological" means metabolism senescence, important evolutionary, physiological, clinical implications.
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