Eco-friendly synthesis of functionalized chitosan-based nanoantibiotic system for potential delivery of linezolid as antimicrobial agents

摘要: Abstract To obtain a healthy human being with beneficial microflora against different pathogenic infections, classical antibiotics nanosized biomaterials were used to inhibit the growth of bacterium by their potent synergistic effect. Hence, this study planned load an oxazolidinone antibiotic named linezolid (LD) onto functionalized chitosan (CN) 3, 5- dinitrosalyslic acid (DA) via microwave synthesis without harsh condition. The exploring effect CN/DA controllable nanostructure was compact efflux-mediated methicillin-resistant Staphylococcus aureus (MRSA) burden and other selected bactericide Gram-positive ((S. aureus), Gram-negative (E. coli), Fungi (C. albicans), Yeast (A. niger), E. faecalis. obtained results showed that LD incorporated into both internal external surface aggregated nanosystem average diameter 150 nm ± 4 hints drug loading. Owing nature CN, release efficiency attains 98.4% within 100 min. designed LD@CN/DA exhibited inhibition zone 54 mm, 59 mm, 69 mm, 57 mm, 24 mm tested microbes respectively rather than individual LD. major target current research is achieved using as nanoantibiotic system has exceptional consistently active multi-resistant pathogens, in between MRSA which resist Also, cell viability performed even after three days direct culture on nanoantibiotic. mechanism microbial correlated rationalized charges presence oxygen species infections. Our findings provide deep explanation about nanostructured design enhanced potentially pathogen-specific activity.