A new bioerodible polymer insert for the controlled release of metronidazole.

摘要: This study evaluates a new class of bioerodible polymers as periodontal inserts for the controlled release metronidazole. The system is based on association formed from compatible blends cellulose acetate phthalate (CAP) and hydrophobic block copolymer polyoxyethylene polyoxypropylene, Pluronic L101. In addition to characterizing these by thermal analysis, their erosion metronidazole characteristics were determined both in vitro, vivo using rat model. results show that increasing concentration L101 blend 50% above leads sharp reduction rates polymer release. slowly eroding films are potentially suitable use drug with an effective duration up several days. Depending composition, mechanism was found range surface erosion-controlled process erosion-modulated diffusion process. all experiments, no signs adverse tissue reactions detected. Based results, prototype delivery designed subsequently evaluated volunteer patients. Preliminary this pilot gingival crevicular fluid significant throughout sampling period 3 hr remained well minimum inhibitory most pathogens. addition, discomfort or irritation reported test subjects.