The effect of Pluronic on the protein release kinetics of an injectable drug delivery system

摘要: Abstract A new class of injectable controlled release depots has been prepared by incorporating materials that preferentially segregate during phase inversion. These consist blends poly(ethylene oxide) (PEO)/poly(propylene (PPO)/poly(ethylene (PEO) triblock copolymers (Pluronics) with poly( d,l -lactide) (PDLA)/1-methyl-2-pyrrolidinone (NMP) solutions. The effects preferential segregation on the inversion dynamics and in vitro protein kinetics were examined using dark ground imaging, high performance liquid chromatography (HPLC), scanning electron microscopy (SEM), confocal microscopy. Variations Pluronic concentration molecular weight had an insignificant effect internal depot morphologies, however, increasing did result increased separation rates and, surprisingly, a decrease magnitude burst, though profiles still retained typical burst-type shape. Additionally, beyond critical point resulted transition from profile to extended-release profile. An interpretation these results terms qualitative model for mechanism is also given.