Effect of the Subcutaneous Environment on Phase-Sensitive In Situ-Forming Implant Drug Release, Degradation, and Microstructure.

摘要: In situ-forming implants are a promising platform used for the release of therapeutic agents. Significant changes in behavior occur when vivo relative to formed vitro. To understand how injection site effects implant behavior, poly(lactic-co-glycolic acid) were examined after subcutaneous space Sprague-Dawley rat model determine environment altered erosion, degradation, swelling, microstructure, and mock drug release. Changes microstructure occurred over time vivo, where it was observed that porosity lost course 5 days. Implants had significantly greater burst (p < 0.05) However, during diffusion period release, vitro higher daily (2.1%/day, p 0.05), which correlated microstructure. Additionally, two-fold increase first-order degradation kinetics vivo. These findings suggest as result induced by external environment.