Effects of ethyl benzoate on performance, morphology, and erosion of PLGA implants formed in situ
作者： R. Astaneh , M. Erfan , J. Barzin , H. Mobedi , HR. Moghimi
DOI: 10.1002/ADV.20114
关键词:
摘要: An in situ forming implant (ISFI) is a novel drug delivery system used for protein and peptide delivery, especially cancer treatment. ISFI based on 33% (w/w) poly(D,L-lactide-co-glycolide)(PLGA; 50:50)/3% leuprolide acetate (LA)/64% N-methyl-2-pyrrolidone (NMP) was prepared this study. After injection of the final formulation, which viscous liquid to an aqueous medium, it deforms become semisolid or solid matrix. The performance matrix investigated basis release from it. Erosion morphology were also studied. effects adding 12.8% ethyl benzoate (EB) as rate-modifying agent performance, erosion, assessed. containing EB showed very low burst (5.53% ± 0.82%) turns closed pore-like structures. EB, This type has close relation well. Finally, effect explained by means solvent–nonsolvent affinity, water permeation, rate phase inversion. © 2008 Wiley Periodicals, Inc. Adv Polym Techn 27:17–26, 2008; Published online InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20114
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