Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children undergoing hypospadius surgery.

摘要: BACKGROUND: The present study was designed to assess whether an intraoperative administration of dexmedetomidine would decrease the and postoperative analgesic requirements for paediatric patients undergoing hypospadius surgery. METHODS: Forty-eight children (American Society Anesthesiologists-1) aged 1-12 years repair under general anaesthesia were randomly assigned into or placebo groups, D P, respectively. Group received a loading dose 1 microg kg(-1) after induction anaesthesia, followed by continuous infusion at rate 0.7 h(-1). P volume-matched 0.9% saline. Both groups fentanyl analgesia intravenous morphine oral paracetamol analgesia. For both heart rate, blood pressure recorded intraoperatively. During their stay 2 h in recovery room, pressure, pain scores, behaviour scores total recorded. After discharge from postanaesthesia care unit, over 24 also RESULTS: Intraoperatively, dexmedetomidine-treated group had significantly fewer requirements, slower lower mean arterial (P < 0.001). In this consumed less morphine, score immediate period, rates pressures when compared with than ward h. CONCLUSION: Intravenous intraoperatively during reduces lowers pressure.