Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children Evidence From a Meta-Analysis

摘要: Several studies have explored the use of serum procalcitonin (PCT) in differentiating between bacterial and viral etiologies children with suspected meningitis. We pooled these into a meta-analysis to determine PCT diagnostic accuracy. All major databases were searched through March 2015. No date or language restrictions applied. Eight (n = 616 pediatric patients) included. Serum assay was found be very accurate for etiology meningitis sensitivity specificity 0.96 (95% CI 0.92-0.98) 0.89 0.86-0.92), respectively. The positive likelihood ratio, negative odds ratio (DOR), area under curve (AUC) 7.5 5.6-10.1), 0.08(95% 0.04-0.14), 142.3 59.5-340.4), 0.97 (SE 0.01), In 6 studies, superior than CRP, whose DOR only 16.7 (95%CI 8.8-31.7). Our demonstrates that is highly powerful test rapidly children.