Association between the ENPP1 K121Q Polymorphism and Risk of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis

摘要: The potential association between the K121Q (A/C, rs1044498) polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, effect this variant on DKD is still under debate, conflicting results have reported. To date, no meta-analysis evaluated with DKD. This paper describes first conducted to evaluate whether ENPP1K121Q associated A literature search was identify all case-control or cross-sectional studies that associations Pooled odds ratios (OR) 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant recessive inheritance models. Seven eligible inclusion meta-analysis, providing data 3571 type 1 2 patients (1606 cases 1965 controls without complication). No significant heterogeneity observed among included when assuming different models (I² 0.10 entire sample after stratification by ethnicity). Meta-analysis revealed Asians Europeans analyzed. most powerful additive model (OR = 1.74, CI 1.27-2.38 total sample). In conclusion, present detected a increased susceptibility European Asian populations.