The role of B cells in solid organ transplantation

摘要: The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either intentional weaning maintenance agents or due homeostatic repopulation after immune cell depletion, the threshold B activation may be lowered. In human transplant recipients result donor-specific antibody, C4d+ injury, and rejection. This scenario precise parallels a rhesus monkey renal allograft model which T cells are depleted with CD3 immunotoxin, CD52-T transgenic mouse using alemtuzumab deplete cells. Such animal models useful testing therapeutic strategies prevent DSA. agree others who suggest immunosuppression place at risk antibody-mediated rejection, this needed if we improve long-term graft patient outcomes transplantation. believe will play crucial defining pathophysiology rejection developing effective therapies injury. Two such described herein.