The Antiproliferative Activity of DMDC Is Modulated by Inhibition of Cytidine Deaminase

作者: Kaori F.-Ouchi , Hideo Ishitsuka , Hiroyuki Eda , Masanori Miwa , Masako Ura

DOI:

关键词:

摘要: … Furthermore, tumor cells transfected with the gene of human Cyd deaminase become more susceptible to DMDC both in vitro and in vivo. These results indicate that Cyd deaminase is …

参考文章(7)
T S Chan, B D Lakhchaura, T F Hsu, Differences in deoxycytidine metabolism in mouse and rat. Biochemical Journal. ,vol. 210, pp. 367- 371 ,(1983) , 10.1042/BJ2100367
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Shin-Ichi Watanabe, Takafumi Uchida, Expression of cytidine deaminase in human solid tumors and its regulation by 1 α,25-dihydroxyvitamin D3 Biochimica et Biophysica Acta. ,vol. 1312, pp. 99- 104 ,(1996) , 10.1016/0167-4889(96)00024-9
Ronald J. Harkrader, Robert C. Jackson, Donald A. Ross, George Weber, Increase in liver and kidney deoxycytidine kinase activity linked to neoplastic transformation. Biochemical and Biophysical Research Communications. ,vol. 96, pp. 1633- 1639 ,(1980) , 10.1016/0006-291X(80)91361-3
Arthur R. Hanze, Nucleic acids. IV. Catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors) Journal of the American Chemical Society. ,vol. 89, pp. 6720- 6725 ,(1967) , 10.1021/JA01001A057
P. Huang, W. Plunkett, C. E. Searcy, V. Gandhi, Gemcitabine: preclinical pharmacology and mechanisms of action. Seminars in Oncology. ,vol. 23, pp. 3- 15 ,(1996)
Neff T, Blau Ca, Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Experimental Hematology. ,vol. 24, pp. 1340- 1346 ,(1996)