Deciphering the molecular genetic basis of NPC through functional approaches.

摘要: The identification of cancer genes in sporadic cancers has been recognized as a major challenge the field. It is clear that deletion mapping, genomic sequencing, comparative hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor (TSGs) from huge array lost regions observed nasopharyngeal carcinoma (NPC). In addition, epigenetically silenced by mapping deleted regions. this review, we describe how functional approaches using monochromosome transfer may be used to circumvent above problems and identify TSGs NPC. A few examples selected NPC their roles are reviewed. They regulate variety functions including cell growth proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, angiogenesis. These studies show advantages for TSGs.