摘要: Oesophageal cancers are prominent worldwide; however, there few targeted therapies and survival rates for these remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas the oesophagus derived from Western Eastern populations. Beyond known histopathological epidemiologic distinctions, features differentiated oesophageal squamous cell adenocarcinomas. resembled other organs more than they did Our analyses identified three subclasses carcinomas, but none showed evidence an aetiological role human papillomavirus. Squamous frequent genomic amplifications CCND1 SOX2 and/or TP63, whereas ERBB2, VEGFA GATA4 GATA6 were commonly amplified in adenocarcinomas strongly chromosomally unstable variant gastric adenocarcinoma, suggesting that could be considered single disease entity. However, some features, including DNA hypermethylation, occurred disproportionally These data provide framework to facilitate rational categorization tumours foundation new therapies.
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