Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study

摘要: We evaluated comorbidity, hospitalization, and mortality in chronic obstructive pulmonary disease (COPD), with special attention to risk factors for frequent hospitalizations (more than three during the follow-up period), prognostic death. Two hundred eighty-eight consecutive COPD patients admitted respiratory medicine wards four hospitals acute exacerbation were enrolled from 1999 2000 a prospective longitudinal study, followed up until December 2007. The Charlson index without age was used quantify comorbidity. Clinical biochemical parameters function data as potential predictive of hospitalization. FEV1, RV, PaO2, PaCO2 develop an functional impairment (REFI index). Hypertension most common comorbidity (64.2%), by renal failure (26.3%), diabetes mellitus (25.3%), cardiac diseases (22.1%). Main causes hospitalization (41.2%) cardiovascular (34.4%). Most 56 deaths (19.4%) due (67.8%). Mortality depended on age, current smoking, REFI index, presence cor pulmonale, ischemic heart disease, lung cancer. Number length hospital admissions degree dyspnea index. correct management implementation aggressive strategies prevent or treat comorbidities are necessary better care patients.