Ethical Considerations in Pharmacogenomics

摘要: The science of pharmacogenomics holds the promise to change way in which clinical drug trials are conducted as well prescription drugs on a routine basis. However, there number ethical and regulatory challenges such subject recruitment, privacy, sample collection storage, confidentiality, major concern for conducting genomics-based studies. Stratification study subjects into subgroups basis genotype is another problem designing studies might lead selection biases. This could also spurious interpretations statistical analysis. Subtype stratification can result scientific data analysis because penetrance. variable degree clinically relevant phenotypic expression genetic variation false positives. Moreover, discrimination by job providers insurance firms other issues legal considerations need be answered. development orphan phenotype. If new molecule being developed only subpopulation patients, then distributive justice fairness accept considered. No doubt emerging boon medical fraternity; however, translation practice requires frame address along with incentives overcome these roadblocks.