Association of ALOX12 gene polymorphism with all-cause and cardiovascular mortality in diabetic nephropathy.

摘要: Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and type 2 diabetes mellitus (DM2). The combination CKD DM2 elevates risk both cardiovascular (CVD) this high-risk population. Besides traditional factors, such as dyslipidemia, smoking, obesity, carotid atherosclerosis, novel factors under investigation genetic polymorphisms. Lipoxygenases (LOXs) their genes critical importance oxidative stress, inflammation, atherosclerosis. aim study is to clarify a potential ALOX12 role CVD presence progress diabetic different stages nephropathy. We studied 145 documented history for at least 10 years nephropathy (DN), mean age 68 ± 9 years, body mass index 31 ± 5 kg/m2, disease, depending on glomerular filtration rate. sample population consisted two groups: 108 DN all five 37 controls. Anthropometric clinical characteristics, interview previous CV event, assessment intima-media thickness (cIMT) were recorded baseline. All genotyped polymorphisms focus rs14309. Genotypes (AA, AG, GG) evaluated any possible CVD, grouping was performed A genotype, which dominant model. participants followed over period 7 years, end points all-cause mortality, events. defined myocardial infarction (MI), stroke, or peripheral artery disease. GG genotype has been significantly associated cIMT levels above 0.86 mm MI. Regarding an atherosclerotic plaque either artery, no significant association found when genotypes assessed own. After grouping, though, revealed between formation atheromatosis. Kaplan–Meier analysis that gene predicted Similarly, AA AG grouped, showed presented even more higher compared combined. adjustment several multivariate Cox proportional hazard had threefold increase twofold increased genotype. rs14309 expression be MI, cIMT, events, CV, overall mortality. This phenomenon could partially explained by platelet proaggregatory activity products control they exert thrombotic occurrence formation.