Topotecan Lactone Selectively Binds to Double- and Single-Stranded DNA in the Absence of Topoisomerase I
作者： Peddaiahgari Seetharamulu , Pavankumar N.V. Petluru , Kochat Haridas , Dhanabalan Murali , Dasharatha G. Reddy
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摘要: We report the first experimental observation that a clinically important camptothecin [CPT; topotecan (TPT), water-soluble CPT] binds directly and noncovalently to double-stranded DNA single-stranded structures in absence of topoisomerase I, but only lactone form. observed clear sequence specificity TPT binding duplex DNA, which was comprised alternating purine-pyrimidine sequences contained dT. These structural studies direct lactone-DNA support several considerations involving possible mechanism(s) anticancer activity CPT-type drugs containing 20( S ) moiety.
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Danzhou Yang, J. Thompson Strode, H. Peter Spielmann, Andrew H.-J. Wang, Thomas G. Burke, DNA Interactions of Two Clinical Camptothecin Drugs Stabilize Their Active Lactone Forms Journal of the American Chemical Society. ,vol. 120, pp. 2979- 2980 ,(1998) , 10.1021/JA973433J
Thomas G. Burke, Zihou Mi, The structural basis of camptothecin interactions with human serum albumin : impact on drug stability Journal of Medicinal Chemistry. ,vol. 37, pp. 40- 46 ,(1994) , 10.1021/JM00027A005
Robert P. Hertzberg, Mary Jo Caranfa, Kenneth G. Holden, Dalia R. Jakas, Gregory Gallagher, Michael R. Mattern, Shau Ming Mong, Joan O'Leary Bartus, Randall K. Johnson, William D. Kingsbury, Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. Journal of Medicinal Chemistry. ,vol. 32, pp. 715- 720 ,(1989) , 10.1021/JM00123A038
Eigil Kjeldsen, Steen Mollerup, Bo Thomsen, Bjarne Juul Bonven, Lars Bolund, Ole Westergaard, Sequence-dependent effect of camptothecin on human topoisomerase I DNA cleavage. Journal of Molecular Biology. ,vol. 202, pp. 333- 342 ,(1988) , 10.1016/0022-2836(88)90462-7
W. J. Slichenmyer, E. K. Rowinsky, R. C. Donehower, S. H. Kaufmann, The Current Status of Camptothecin Analogues as Antitumor Agents Journal of the National Cancer Institute. ,vol. 85, pp. 271- 291 ,(1993) , 10.1093/JNCI/85.4.271
A. Tanizawa, A. Fujimori, Y. Fujimori, Y. Pommier, Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical Trials Journal of the National Cancer Institute. ,vol. 86, pp. 836- 842 ,(1994) , 10.1093/JNCI/86.11.836
B. Giovanella, J. Stehlin, M. Wall, M. Wani, A. Nicholas, L. Liu, R Silber, M Potmesil, DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts Science. ,vol. 246, pp. 1046- 1048 ,(1989) , 10.1126/SCIENCE.2555920
Robert P. Hertzberg, Mary Jo Caranfa, Sidney M. Hecht, On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex Biochemistry. ,vol. 28, pp. 4629- 4638 ,(1989) , 10.1021/BI00437A018
M E Wall, M C Wani, Antineoplastic Agents from Plants Annual Review of Pharmacology and Toxicology. ,vol. 17, pp. 117- 132 ,(1977) , 10.1146/ANNUREV.PA.17.040177.001001